Our Team​​
Munich, Germany (Partner 1)
PI & IMMOSCAN coordinator: Hanna Taipaleenmäki, post-doc: Amy Ribet
The German team is based at the Institute of Musculoskeletal Medicine at the University Hospital of Ludwig-Maximilians-University (LMU) Munich. Our research focuses on breast cancer bone metastases, the bone microenvironment, and osteoclast biology. We bring strong conceptual and technical expertise in preclinical models, advanced histological techniques, and molecular biology methods to investigate key osteoclast-mediated mechanisms driving bone metastases progression.
To find out more about the Institute of Musculoskeletal Medicine, click here.
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L'Aquila, Italy (Partner 2)
PI: Anna Maria Teti & Vincenzo Flati, post-doc: Jacopo Di Gregorio
The Italian team is based in the Department of Biotechnological and Applied Clinical Sciences at the University of L'Aquila. Our research main interest is on bone metastasis but we are also interested in studies on the molecular basis of other pathologies. Our expertise ranges from in vitro to in vivo studies employing molecular and cell biology techniques to investigate the signal transduction pathways involved in cancer growth and metastasis.
To see more information about the IMMOSCAN project, click here.
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Nantes, France (Partner 3)
PI: Dominique Heymann, post-doc: Daria Klusa
Tumor Heterogeneity and Precision Medicine Lab is associated with the University of Nantes and is located at the Institut de cancérologie de l'Ouest. Our research is focused on osteosarcoma, cancer stem cells, circulating tumor cells and the tumor microenvironment. To understand the role of osteoclasts in osteosarcoma development, we bring expertise in 3D in vitro cultures, animal models, histological analyses and standard molecular biology techniques. In addition to established cell lines, we use primary murine material and human samples.
To learn more about our department, click here. ​
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Nice, France (Partner 4)
PI: Claudine Blin-Wakkach, post-doc: Maria Materozzi
The team "Osteoimmunology, niches and inflammation" is located in Nice, France, in the Laboratory of Molecular PhysioMedicine. It is part of the CNRS (National Center for Scientific Research) and Université Côte d’Azur.
Our major objectives are to understand how the bone and immune systems interact and determine how these interactions contribute to maintaining bone and immune-hematological homeostasis. They are conducted both in a physiological context (growth, aging) and in the context of chronic inflammatory diseases associated with bone defects, osteoporosis and bone tumors. For this, we are developing in vivo and in vitro models, combined with functional and mechanistic studies, large-scale transcriptomic and proteomic analyses, research of biomarkers and new therapeutic targets.
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As a team specialized in osteoimmunology, we are characterizing the immune function and the origin of cancer-associated osteoclasts using transcriptomic approaches, computational analysis, spectral cytometry and functional assays in vitro and in vivo.
​​​To learn more about team, click here. ​
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Odense, Denmark (Partner 5)
PI: Thomas Levin Andersen ​& Christina Møller Andreasen
The Danish Molecular Bone Histology Lab utilizes cutting-edge Xenium 10X single-cell spatial imaging to map gene expression profiles of immune osteoclasts within the bone microenvironment of osteosarcoma and breast cancer patients with bone metastases.
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